Maurizio D'Incalci Selected Research

3- (4'- hydroxy- 3'- adamantylbiphenyl- 4- yl)acrylic acid

8/2012	Enhanced cell cycle perturbation and apoptosis mediate the synergistic effects of ST1926 and ATRA in neuroblastoma preclinical models.
10/2009	Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of ST1926, a novel oral antitumor agent, adamantyl retinoid derivative, in plasma of patients in a Phase I study.
3/2007	The novel atypical retinoid ST1926 is active in ATRA resistant neuroblastoma cells acting by a different mechanism.

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Maurizio D'Incalci Research Topics

Disease

110	Neoplasms (Cancer) 07/2022 - 01/2002
27	Ovarian Neoplasms (Ovarian Cancer) 04/2022 - 04/2004
17	Sarcoma (Soft Tissue Sarcoma) 11/2020 - 12/2002
15	Myxoid Liposarcoma 01/2022 - 07/2007
12	Carcinoma (Carcinomatosis) 01/2017 - 04/2002
10	Ovarian Epithelial Carcinoma 05/2021 - 01/2012
8	Breast Neoplasms (Breast Cancer) 01/2022 - 11/2003
6	Malignant Mesothelioma 07/2022 - 01/2017
6	Disease Progression 01/2022 - 03/2016
6	Neoplasm Metastasis (Metastasis) 01/2020 - 08/2003
6	Liposarcoma 01/2019 - 07/2007
6	Melanoma (Melanoma, Malignant) 01/2019 - 03/2003
4	Colonic Neoplasms (Colon Cancer) 08/2020 - 02/2009
4	Inflammation (Inflammations) 08/2020 - 04/2005
4	Multiple Myeloma 01/2019 - 04/2010
4	Colorectal Neoplasms (Colorectal Cancer) 01/2018 - 07/2012
4	Triple Negative Breast Neoplasms 01/2017 - 02/2013
4	Ewing Sarcoma (Sarcoma, Ewing) 11/2016 - 12/2002
4	Neuroblastoma 08/2012 - 10/2005
3	Neutropenia 11/2020 - 03/2005
3	Leiomyosarcoma 01/2018 - 07/2010
3	Mesothelioma 01/2017 - 01/2015
3	Rhabdomyosarcoma 09/2010 - 08/2003
3	Chromosome Aberrations (Chromosome Abnormalities) 09/2009 - 12/2005
2	Fibrosarcoma 11/2021 - 08/2003
2	Glioblastoma (Glioblastoma Multiforme) 05/2019 - 10/2013
2	Adenocarcinoma 01/2018 - 03/2016
2	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 08/2017 - 12/2016
2	Seizures (Absence Seizure) 03/2017 - 07/2002
2	Epilepsy (Aura) 03/2017 - 07/2002
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 09/2011 - 02/2008

Drug/Important Bio-Agent (IBA)

55	TrabectedinIBA 01/2022 - 01/2002
38	Pharmaceutical PreparationsIBA 01/2022 - 07/2002
15	PlatinumIBA 01/2022 - 03/2005
14	Antineoplastic Agents (Antineoplastics)IBA 01/2022 - 04/2002
11	Biomarkers (Surrogate Marker)IBA 05/2022 - 07/2006
11	Proteins (Proteins, Gene)FDA Link 01/2020 - 02/2003
10	Paclitaxel (Taxol)FDA LinkGeneric 09/2021 - 09/2006
9	MicroRNAs (MicroRNA)IBA 07/2021 - 07/2012
8	Biological ProductsIBA 07/2022 - 11/2004
8	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 04/2004
8	Cisplatin (Platino)FDA LinkGeneric 07/2019 - 12/2002
6	CytokinesIBA 08/2020 - 04/2005
5	PM 01183IBA 01/2022 - 11/2013
5	Irinotecan (Camptosar)FDA LinkGeneric 11/2016 - 09/2005
4	Imatinib Mesylate (Gleevec)FDA Link 11/2017 - 05/2002
4	Gemcitabine FDA Link 01/2017 - 02/2008
4	Doxorubicin (Adriamycin)FDA LinkGeneric 12/2016 - 08/2003
4	liposomal doxorubicin (Doxil)FDA Link 11/2016 - 08/2010
4	ChemokinesIBA 04/2016 - 03/2010
4	Telomerase (Telomerase Reverse Transcriptase)IBA 12/2005 - 03/2003
3	Pioglitazone (Actos)FDA Link 01/2022 - 12/2019
3	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2022 - 08/2013
3	olaparibIBA 01/2022 - 10/2018
3	Bevacizumab (Avastin)FDA Link 01/2021 - 01/2016
3	AnthracyclinesIBA 11/2020 - 12/2011
3	Interleukin-6 (Interleukin 6)IBA 08/2020 - 04/2005
3	RNA (Ribonucleic Acid)IBA 11/2018 - 01/2012
3	Asparaginase (Elspar)FDA Link 04/2018 - 01/2006
3	Tyrosine Kinase InhibitorsIBA 11/2017 - 02/2013
3	OTX015IBA 01/2017 - 12/2016
3	Ifosfamide FDA LinkGeneric 11/2016 - 12/2011
3	LigandsIBA 11/2015 - 11/2008
3	plitidepsin (aplidine)IBA 01/2014 - 02/2004
3	E-3810IBA 02/2013 - 02/2011
3	3- (4'- hydroxy- 3'- adamantylbiphenyl- 4- yl)acrylic acidIBA 08/2012 - 03/2007
3	RetinoidsIBA 08/2012 - 03/2007
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2011 - 11/2009
3	ST 1481 (Gimatecan)IBA 09/2010 - 10/2005
2	Circulating Tumor DNAIBA 01/2021 - 01/2018
2	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2021 - 09/2003
2	Carboplatin (JM8)FDA LinkGeneric 01/2021 - 10/2019
2	Alanine Transaminase (SGPT)IBA 01/2021 - 10/2018
2	Transaminases (Aminotransferases)IBA 11/2020 - 03/2005
2	Macrophage Colony-Stimulating FactorIBA 08/2020 - 04/2005
2	Tissue Inhibitor of Metalloproteinase-1IBA 01/2019 - 02/2015
2	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 10/2018 - 08/2013
2	Carbamazepine (Tegretol)FDA LinkGeneric 03/2017 - 07/2002
2	Anticonvulsants (Antiepileptic Drugs)IBA 03/2017 - 07/2002
2	Progesterone FDA LinkGeneric 01/2017 - 08/2013
2	Estrogens (Estrogen)FDA Link 01/2017 - 08/2013
2	EWS-FLI fusion proteinIBA 11/2016 - 03/2014
2	Transcription Factors (Transcription Factor)IBA 11/2016 - 08/2012
2	Matrix Metalloproteinases (MMPs)IBA 07/2016 - 02/2013
2	Small Interfering RNA (siRNA)IBA 03/2016 - 03/2014
2	CamptothecinIBA 03/2014 - 10/2005
2	Sunitinib (Sutent)FDA Link 10/2013 - 02/2011
2	Phosphotransferases (Kinase)IBA 02/2013 - 02/2011
2	delanzomibIBA 01/2013 - 11/2010
2	Messenger RNA (mRNA)IBA 08/2012 - 07/2002
2	Oxaliplatin (Eloxatin)FDA LinkGeneric 07/2012 - 09/2011
2	Fluorouracil (Carac)FDA LinkGeneric 09/2011 - 02/2009
2	vandetanib (ZD6474)IBA 01/2010 - 11/2009

Therapy/Procedure

31	Therapeutics 04/2022 - 08/2007
23	Drug Therapy (Chemotherapy) 01/2022 - 12/2002
5	Aftercare (After-Treatment) 01/2022 - 12/2002
3	Immunotherapy 01/2022 - 01/2020
2	Cytoreduction Surgical Procedures 01/2022 - 07/2019
2	Hyperthermic Intraperitoneal Chemotherapy 07/2019 - 01/2017
2	Salvage Therapy 03/2016 - 03/2005